RNA Details
Disease Name
pulmonary fibrosis
Tissue
lung
RNA Symbol
Tsc2
RNA ID
RNA Type
mRNA
Alteration Pattern
down regulation
Species
mus musculus
Detection Methods
Immunohistochemistry; Immunofluorescence; etc.
Target
NA
Pathway
NA
PubMed ID
Title
Repression of TSC1/TSC2 mediated by MeCP2 regulates human embryo lung fibroblast cell differentiation and proliferation
Year
2016
Function
"Expression of TSC1 and TSC2 in fibrotic mice lung was reduced and in HELF cells with TGF-B1stimulation. In addition, overexpression of TSC1 or TSC2 decreased cell proliferation and differentiation. Reduced expression of TSC1 and TSC2 caused by TGF-B1 is associated with the promoter methylation status of TSC1 and TSC2. Expression of TSC1 and TSC2 can be repressed by MeCP2, which regulates HELF cell differentiation and proliferation as myofibroblasts and lead to PF."